ZFIN is now using GRCz12tu for Genomic Data
Gene
tln2a
- ID
- ZDB-GENE-040724-263
- Name
- talin 2a
- Symbol
- tln2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in actin cytoskeleton organization and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cytoskeleton and ruffle. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Is expressed in brain; ectoderm; head; paraxial mesoderm; and somite. Orthologous to human TLN2 (talin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wu et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR002404 | IRS-type PTB domain |
| Domain | IPR002558 | I/LWEQ domain |
| Domain | IPR015009 | Vinculin-binding site-containing domain |
| Domain | IPR015224 | Talin, central |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR032425 | Talin, N-terminal F0 domain |
| Domain | IPR037438 | Talin-1/2, rod-segment |
| Domain | IPR049108 | Talin, R4 domain |
| Domain | IPR054060 | Talin 1-like, rod-segment domain |
| Domain | IPR054082 | Talin, IBS2B domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR035964 | I/LWEQ domain superfamily |
| Homologous_superfamily | IPR036476 | Talin, central domain superfamily |
| Homologous_superfamily | IPR036723 | Alpha-catenin/vinculin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Ubiquitin-like domain superfamily | Vinculin-binding site-containing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z7P4 | InterPro | 2548 | ||||||||||||||||||||
| UniProtKB:A0A8M2BG54 | InterPro | 2545 | ||||||||||||||||||||
| UniProtKB:A0A0R4IIA7 | InterPro | 2543 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers