ZFIN is now using GRCz12tu for Genomic Data
Gene
cacna1aa
- ID
- ZDB-GENE-040724-26
- Name
- calcium voltage-gated channel subunit alpha1 Aa
- Symbol
- cacna1aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in heart and nervous system. Used to study Dravet syndrome and absence epilepsy. Human ortholog(s) of this gene implicated in epilepsy (multiple); migraine (multiple); and neurodegenerative disease (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1553 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 42 | Alliance | Developmental and epileptic encephalopathy 42 | 617106 |
| episodic ataxia type 2 | Alliance | Episodic ataxia, type 2 | 108500 |
| familial hemiplegic migraine 1 | Alliance | Migraine, familial hemiplegic, 1 | 141500 |
| familial hemiplegic migraine 1 | Alliance | Migraine, familial hemiplegic, 1, with progressive cerebellar ataxia | 141500 |
| spinocerebellar ataxia 6 | Alliance | Spinocerebellar ataxia 6 | 183086 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Dravet syndrome | AB + MO1-cacna1aa + MO2-cacna1aa | standard conditions | Nieoczym et al., 2026 |
| absence epilepsy | AB + MO1-cacna1aa + MO2-cacna1aa | standard conditions | Gawel et al., 2019 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1aa-201
(1)
|
Ensembl | 6,798 nt | ||
| mRNA |
cacna1aa-202
(1)
|
Ensembl | 5,851 nt | ||
| mRNA |
cacna1aa-203
(1)
|
Ensembl | 5,848 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers