Gene
guca1d
- ID
- ZDB-GENE-040724-231
- Name
- guanylate cyclase activator 1d
- Symbol
- guca1d Nomenclature History
- Previous Names
-
- gcap4 (1)
- si:rp71-1p14.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Is expressed in eye; retina; retinal cone cell; and retinal outer nuclear layer. Orthologous to human GUCA1C (guanylate cyclase activator 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa25160 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Recoverin family |
|---|---|---|---|---|---|---|
| UniProtKB:Q6ZM98 | InterPro | 185 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
guca1d-201
(1)
|
Ensembl | 744 nt | ||
| mRNA |
guca1d-202
(1)
|
Ensembl | 729 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-115D3 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1P14 | ||
| Encodes | cDNA | MGC:171365 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194425 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194431 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001011661 (1) | 558 nt | ||
| Genomic | GenBank:AL627325 (1) | 163882 nt | ||
| Polypeptide | UniProtKB:Q6ZM98 (1) | 185 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | GUCA1C | 3 | Amino acid sequence comparison (1) |
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Shi, W.J., Huang, G.Y., Jiang, Y.X., Ma, D.D., Chen, H.X., Huang, M.Z., Hou, L.P., Xie, L., Ying, G.G. (2020) Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish. Ecotoxicology and environmental safety. 193:110371
- Shi, W.J., Jiang, Y.X., Ma, D.D., Huang, G.Y., Xie, L., Chen, H.X., Huang, M.Z., Ying, G.G. (2019) Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish. Ecotoxicology and environmental safety. 183:109556
- Lim, S., Scholten, A., Manchala, G., Cudia, D., Zlomke-Sell, S.K., Koch, K.W., Ames, J.B. (2017) Structural Characterization of Ferrous Ion Binding to Retinal Guanylate Cyclase Activator Protein-5 from Zebrafish Photoreceptors. Biochemistry. 56(51):6652-6661
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Pinto, C.L., Kalasekar, S.M., McCollum, C.W., Riu, A., Jonsson, P., Lopez, J., Swindell, E., Bouhlatouf, A., Balaguer, P., Bondesson, M., Gustafsson, J.Å. (2016) Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Molecular and Cellular Endocrinology. 419:29-43
- Sulmann, S., Vocke, F., Scholten, A., Koch, K.W. (2015) Retina specific GCAPs in zebrafish acquire functional selectivity in Ca(2+)-sensing by myristoylation and Mg(2+)-binding. Scientific Reports. 5:11228
- Fries, R., Scholten, A., Säftel, W., and Koch, K.W. (2013) Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. PLoS One. 8(8):e69656
- Behnen, P., Scholten, A., Rätscho, N., and Koch, K.W. (2009) The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 14(1):89-99
- Rätscho, N., Scholten, A., and Koch, K.W. (2009) Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochimica et biophysica acta. Molecular cell research. 1793(6):1110-1114
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