Gene
guca1d
- ID
- ZDB-GENE-040724-231
- Name
- guanylate cyclase activator 1d
- Symbol
- guca1d Nomenclature History
- Previous Names
-
- gcap4 (1)
- si:rp71-1p14.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in photoreceptor outer segment. Is expressed in eye; retina; retinal cone cell; and retinal outer nuclear layer. Orthologous to human GUCA1C (guanylate cyclase activator 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa25160 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Recoverin family |
---|---|---|---|---|---|---|
UniProtKB:Q6ZM98 | InterPro | 185 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
guca1d-201
(1)
|
Ensembl | 744 nt | ||
mRNA |
guca1d-202
(1)
|
Ensembl | 729 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-115D3 | ZFIN Curated Data | |
Contained in | BAC | RP71-1P14 | ||
Encodes | cDNA | MGC:171365 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194425 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194431 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001011661 (1) | 558 nt | ||
Genomic | GenBank:AL627325 (1) | 163882 nt | ||
Polypeptide | UniProtKB:Q6ZM98 (1) | 185 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | GUCA1C | 3 | Amino acid sequence comparison (1) |
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Shi, W.J., Huang, G.Y., Jiang, Y.X., Ma, D.D., Chen, H.X., Huang, M.Z., Hou, L.P., Xie, L., Ying, G.G. (2020) Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish. Ecotoxicology and environmental safety. 193:110371
- Shi, W.J., Jiang, Y.X., Ma, D.D., Huang, G.Y., Xie, L., Chen, H.X., Huang, M.Z., Ying, G.G. (2019) Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish. Ecotoxicology and environmental safety. 183:109556
- Lim, S., Scholten, A., Manchala, G., Cudia, D., Zlomke-Sell, S.K., Koch, K.W., Ames, J.B. (2017) Structural Characterization of Ferrous Ion Binding to Retinal Guanylate Cyclase Activator Protein-5 from Zebrafish Photoreceptors. Biochemistry. 56(51):6652-6661
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Pinto, C.L., Kalasekar, S.M., McCollum, C.W., Riu, A., Jonsson, P., Lopez, J., Swindell, E., Bouhlatouf, A., Balaguer, P., Bondesson, M., Gustafsson, J.Å. (2016) Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Molecular and Cellular Endocrinology. 419:29-43
- Sulmann, S., Vocke, F., Scholten, A., Koch, K.W. (2015) Retina specific GCAPs in zebrafish acquire functional selectivity in Ca(2+)-sensing by myristoylation and Mg(2+)-binding. Scientific Reports. 5:11228
- Fries, R., Scholten, A., Säftel, W., and Koch, K.W. (2013) Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. PLoS One. 8(8):e69656
- Behnen, P., Scholten, A., Rätscho, N., and Koch, K.W. (2009) The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 14(1):89-99
- Rätscho, N., Scholten, A., and Koch, K.W. (2009) Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochimica et biophysica acta. Molecular cell research. 1793(6):1110-1114
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