Gene
ift140
- ID
- ZDB-GENE-040724-165
- Name
- intraflagellar transport 140 homolog (Chlamydomonas)
- Symbol
- ift140 Nomenclature History
- Previous Names
-
- si:ch211-153c20.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to be involved in intraciliary retrograde transport. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in retinitis pigmentosa 80 and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Helm et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 80 | Alliance | Retinitis pigmentosa 80 | 617781 |
| short-rib thoracic dysplasia 9 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 9 with or without polydactyly | 266920 |
| Cranioectodermal dysplasia 5 | 621180 | ||
| {Polycystic kidney disease 9, susceptibility to} | 621164 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024336 | tRNA-splicing endonuclease, subunit Sen54, N-terminal |
| Domain | IPR056154 | IFT140, first beta-propeller domain |
| Domain | IPR056155 | IFT140, second beta-propeller domain |
| Domain | IPR056156 | IF140, C-terminal TPR domain |
| Domain | IPR056168 | IF140/IFT172/WDR19, TPR domain |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | IF140, C-terminal TPR domain | IF140/IFT172/WDR19, TPR domain | IFT140, first beta-propeller domain | IFT140, second beta-propeller domain | Tetratricopeptide-like helical domain superfamily | tRNA-splicing endonuclease, subunit Sen54, N-terminal | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q896 | InterPro | 1446 | |||||||||
| UniProtKB:A0A8M9PXA0 | InterPro | 1458 | |||||||||
| UniProtKB:F1QG20 | InterPro | 1445 | |||||||||
| UniProtKB:A0A8M3ANT2 | InterPro | 1457 | |||||||||
| UniProtKB:A0A8M9Q5D1 | InterPro | 669 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
ift140-202
(1)
|
Ensembl | 741 nt | ||
| mRNA |
ift140-201
(1)
|
Ensembl | 4,885 nt | ||
| mRNA |
ift140-203
(1)
|
Ensembl | 4,338 nt |
Interactions and Pathways
No data available
Plasmids
No data available