ZFIN is now using GRCz12tu for Genomic Data
Gene
aqp4
- ID
- ZDB-GENE-040724-152
- Name
- aquaporin 4
- Symbol
- aqp4 Nomenclature History
- Previous Names
-
- si:ch211-192k9.1
- zgc:100922
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables water transmembrane transporter activity. Predicted to be involved in water transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in endosome membrane and sarcolemma. Predicted to be active in basolateral plasma membrane. Is expressed in gill; integument; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Meniere's disease; megalencephalic leukoencephalopathy with subcortical cysts; optic nerve disease (multiple); temporal lobe epilepsy; and transverse myelitis. Orthologous to human AQP4 (aquaporin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting | 620448 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aquaporin-like | Aquaporin transporter | Major intrinsic protein | Major intrinsic protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6AZD2 | InterPro | 320 | ||||
| UniProtKB:A0A2R8Q5A8 | InterPro | 328 | ||||
| UniProtKB:A0AB13A8Z8 | InterPro | 346 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers