Gene

aqp4

ID

ZDB-GENE-040724-152

Name

aquaporin 4

Symbol

aqp4 Nomenclature History

Previous Names

si:ch211-192k9.1
zgc:100922

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Enables water transmembrane transporter activity. Predicted to be involved in water transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in cell projection; endosome membrane; and sarcolemma. Predicted to be active in basolateral plasma membrane. Is expressed in gill; integument; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Meniere's disease; megalencephalic leukoencephalopathy with subcortical cysts; optic nerve disease (multiple); temporal lobe epilepsy; and transverse myelitis. Orthologous to human AQP4 (aquaporin 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aqp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting	620448

Associated With aqp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022357	Major intrinsic protein, conserved site
Family	IPR000425	Major intrinsic protein
Family	IPR034294	Aquaporin transporter
Homologous_superfamily	IPR023271	Aquaporin-like