ZFIN ID: ZDB-GENE-040718-440
Gene Name: GATA binding protein 2b
Gene Symbol: gata2b    Nomenclature History

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Previous Name: zgc:91840 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in definitive hemopoiesis and hematopoietic stem cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including dorsal aorta; hematopoietic cell; hematopoietic system; neurons; and vascular cord. Human ortholog(s) of this gene implicated in acute myeloid leukemia; mental depression; myelodysplastic syndrome; myeloid leukemia; and primary immunodeficiency disease. Orthologous to human GATA2 (GATA binding protein 2).
Genome Resources: Alliance (1),  Gene:436962 (1),  Ensembl(GRCz11):ENSDARG00000009094 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14633 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gata2b
    1
    CRISPR2-gata2b
    1
    MO1-gata2b N/A 2
    MO2-gata2b N/A 1
    DISEASE ASSOCIATED WITH gata2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance {Leukemia, acute myeloid, susceptibility to} 601626
    myelodysplastic syndrome Alliance {Myelodysplastic syndrome, susceptibility to} 614286
    Emberger syndrome 614038
    Immunodeficiency 21 614172
    DISEASE ASSOCIATED WITH gata2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata2b-201 (1)    Ensembl 1955
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(gata2b:KALTA4) gata2b KALTA4 Danio rerio 1 7
    MARKER RELATIONSHIPS
    gata2b Contained in: [BAC] CH211-157B11 (1)
    gata2b Encodes: [cDNA] MGC:91840 (1), MGC:192890 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002689 (1) 1935 nt
    Genomic GenBank:CR450814 (1) 158142 nt
    Select Tool
    Polypeptide UniProtKB:F1QD30 (1) 428 aa
    Sequence Information (all 15)
    ORTHOLOGY for gata2b ( Chr: 6 )
    CITATIONS (40)