Gene
sdhda
- ID
- ZDB-GENE-040718-192
- Name
- succinate dehydrogenase complex, subunit D, integral membrane protein a
- Symbol
- sdhda Nomenclature History
- Previous Names
-
- SDHD2 (1)
- sdhdb
- zgc:92857
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to contribute to succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carney-Stratakis syndrome | Alliance | Paraganglioma and gastric stromal sarcoma | 606864 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 1 | 168000 |
| Mitochondrial complex II deficiency, nuclear type 3 | 619167 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fumarate reductase/succinate dehydrogenase, transmembrane subunit | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS |
|---|---|---|---|
|
UniProtKB:B2GNJ0
|
154 | ||
|
UniProtKB:Q6DGM2
|
154 |
Interactions and Pathways
No data available
Plasmids
No data available