Gene
mcm3ap
- ID
- ZDB-GENE-040715-1
- Name
- minichromosome maintenance complex component 3 associated protein
- Symbol
- mcm3ap Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be part of transcription export complex 2. Predicted to be active in cytoplasm and nucleus. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi471Tg | Transgenic insertion | Exon 2 | Unknown | DNA | |
| sa8980 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13572 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17895 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34707 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41485 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41486 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development | 618124 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR000717 | Proteasome component (PCI) domain |
| Domain | IPR005062 | SAC3/GANP/THP3, conserved domain |
| Domain | IPR031907 | Germinal-centre associated nuclear protein, MCM3AP domain |
| Domain | IPR031910 | Germinal-centre associated nuclear protein, CID domain |
| Domain | IPR034265 | MCM3AP, RNA recognition motif |
| Family | IPR045107 | SAC3/GANP/THP3 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Germinal-centre associated nuclear protein, CID domain | Germinal-centre associated nuclear protein, MCM3AP domain | MCM3AP, RNA recognition motif | Nucleotide-binding alpha-beta plait domain superfamily | Proteasome component (PCI) domain | RNA-binding domain superfamily | RNA recognition motif domain | SAC3/GANP/THP3 | SAC3/GANP/THP3, conserved domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q712 | InterPro | 2118 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mcm3ap-201
(1)
|
Ensembl | 9,091 nt | ||
| mRNA |
mcm3ap-202
(1)
|
Ensembl | 686 nt | ||
| mRNA |
mcm3ap-203
(1)
|
Ensembl | 6,794 nt | ||
| ncRNA |
mcm3ap-002
(1)
|
Ensembl | 686 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-101K6 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-68F9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005167868 (1) | 6833 nt | ||
| Genomic | GenBank:BX001051 (1) | 213486 nt | ||
| Polypeptide | UniProtKB:F1Q712 (1) | 2118 aa |
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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