Gene
mgst1.2
- ID
- ZDB-GENE-040704-59
- Name
- microsomal glutathione S-transferase 1.2
- Symbol
- mgst1.2 Nomenclature History
- Previous Names
-
- mgst1a
- si:dkey-8m7.1
- zgc:92357
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable glutathione transferase activity. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in brain; gill; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human MGST1 (microsomal glutathione S-transferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Microsomal glutathione S-transferase 1-like |
|---|---|---|---|---|---|
| UniProtKB:B0R1E9 | InterPro | 152 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mgst1.2-201
(1)
|
Ensembl | 2,149 nt | ||
| mRNA |
mgst1.2-202
(1)
|
Ensembl | 1,899 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-281G7 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-87C9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92357 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002215 (1) | 2149 nt | ||
| Genomic | GenBank:AL954848 (2) | 170178 nt | ||
| Polypeptide | UniProtKB:B0R1E9 (1) | 152 aa |
- Zhang, J., Ye, Z.W., Bräutigam, L., Chakraborty, P., Luo, Z., Culpepper, J., Aslam, M., Zhang, L., Johansson, K., Haeggström, J.Z., Xu, J., Olsson, M., Townsend, D.M., Mehrotra, S., Morgenstern, R., Tew, K.D. (2023) A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression. The Journal of biological chemistry. 299(8):104920
- Bräutigam, L., Zhang, J., Dreij, K., Spahiu, L., Holmgren, A., Abe, H., Tew, K.D., Townsend, D.M., Kelner, M.J., Morgenstern, R., Johansson, K. (2018) MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biology. 17:171-179
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 158C:50-62
- Zhang, N.S., Li, H.Y., Liu, J.S., Yang, W.D. (2014) Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Environmental Toxicology and Pharmacology. 37:791-802
- Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
- Trinh, A., Hochgreb, T., Graham, M., Wu, D., Ruf-Zamojski, F., Jayasena, C.S., Saxena, A., Hawk, R., Gonzalez-Serricchio, A., Dixson, A., Chow, E., Gonzales, C., Leung, H.Y., Solomon, I., Bronner-Fraser, M., Megason, S.G., and Fraser, S.E. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes & Development. 25(21):2306-20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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