Gene

prpf18

ID

ZDB-GENE-040704-45

Name

PRP18 pre-mRNA processing factor 18 homolog (yeast)

Symbol

prpf18 Nomenclature History

Previous Names

zgc:91830

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to contribute to second spliceosomal transesterification activity. Predicted to be involved in generation of catalytic spliceosome for second transesterification step and nuclear retention of unspliced pre-mRNA at the site of transcription. Predicted to localize to U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Orthologous to human PRPF18 (pre-mRNA processing factor 18).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7140126 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prpf18 Human Ortholog

No data available

Associated With prpf18 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004098	Prp18
Domain	IPR014906	Pre-mRNA processing factor 4 (PRP4)-like
Family	IPR039979	Pre-mRNA-splicing factor 18
Homologous_superfamily	IPR036285	PRP4-like superfamily