Gene
mgat4b
- ID
- ZDB-GENE-040704-19
- Name
- alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Symbol
- mgat4b Nomenclature History
- Previous Names
-
- wu:fc25g12
- zgc:92425
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018807Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14606 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22441 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35655 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44803 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mgat4b | (3) | |
| CRISPR2-mgat4b | Varshney et al., 2015 | |
| CRISPR3-mgat4b | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006759 | Glycosyl transferase family 54 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyl transferase family 54 |
|---|---|---|---|
| UniProtKB:Q6GMK0 | InterPro | 547 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mgat4b-201
(1)
|
Ensembl | 3,199 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-163B9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33H4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-83I22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-177P5 | ZFIN Curated Data | |
| Encodes | EST | fc25g12 | ||
| Encodes | cDNA | MGC:92425 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173869 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002180 (1) | 3205 nt | ||
| Genomic | GenBank:CU075768 (1) | 161271 nt | ||
| Polypeptide | UniProtKB:Q6GMK0 (1) | 547 aa |
- Matheny-Rabun, C., Mokashi, S.S., Radenkovic, S., Wiggins, K., Dukes-Rimsky, L., Angel, P., Ghesquiere, B., Kozicz, T., Steet, R., Morava, E., Flanagan-Steet, H. (2024) O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Cell Reports. 43:114976114976
- Adam, A.C., Lie, K.K., Whatmore, P., Jakt, L.M., Moren, M., Skjærven, K.H. (2019) Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid. PLoS One. 14:e0220934
- Pei, W., Huang, S.C., Xu, L., Pettie, K., Ceci, M.L., Sánchez, M., Allende, M.L., Burgess, S.M. (2016) Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish.. Cell regeneration (London, England). 5:3
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688
- Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
- Hung, I.C., Cherng, B.W., Hsu, W.M., and Lee, S.J. (2013) Calnexin is required for zebrafish posterior lateral line development. The International journal of developmental biology. 57(5):427-438
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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