Gene

ren

ID

ZDB-GENE-040630-3

Name

renin

Symbol

ren Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in angiotensin maturation. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Is expressed in artery; embryonic structure; intermediate mesoderm; and renal system. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ren Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial juvenile hyperuricemic nephropathy	Alliance	Tubulointerstitial kidney disease, autosomal dominant, 4	613092
		Renal tubular dysgenesis	267430
		[Hyperproreninemia]

Associated With ren Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001969	Aspartic peptidase, active site
Domain	IPR033121	Peptidase family A1 domain
Domain	IPR034135	Renin-like domain
Family	IPR001461	Aspartic peptidase A1
Homologous_superfamily	IPR021109	Aspartic peptidase domain superfamily