Gene
cryba2a
- ID
- ZDB-GENE-040625-8
- Name
- crystallin, beta A2a
- Symbol
- cryba2a Nomenclature History
- Previous Names
-
- zgc:86610
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in lens and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract 42. Orthologous to human CRYBA2 (crystallin beta A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2321 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 42 | Alliance | ?Cataract 42 | 115900 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta/gamma crystallin | Beta/Gamma-Crystallin | Gamma-crystallin-like |
|---|---|---|---|---|---|
| UniProtKB:Q6IQU2 | InterPro | 197 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cryba2a-202
(1)
|
Ensembl | 551 nt | ||
| mRNA |
cryba2a-201
(1)
|
Ensembl | 1,051 nt | ||
| mRNA |
cryba2a-203
(1)
|
Ensembl | 867 nt | ||
| mRNA |
cryba2a-204
(1)
|
Ensembl | 782 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-145L22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86610 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002049 (1) | 1076 nt | ||
| Genomic | GenBank:CU929360 (1) | 81719 nt | ||
| Polypeptide | UniProtKB:Q6IQU2 (1) | 197 aa |
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Zhang, Y., Wang, Z., Zhao, G., Liu, J.X. (2018) Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicology and environmental safety. 163:279-288
- Cortelazzo, A., Pietri, T., De Felice, C., Leoncini, S., Guerranti, R., Signorini, C., Timperio, A.M., Zolla, L., Ciccoli, L., Hayek, J. (2017) Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish.. Journal of proteomics. 154:128-133
- Elodie, F., Anne-Sophie, V., Frédéric, S. (2017) Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Aquatic toxicology (Amsterdam, Netherlands). 189:97-107
- Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuzé, A., Casane, D., Rétaux, S. (2015) Lens defects in Astyanax mexicanus cavefish: evolution of crystallins and a role for alphaA-crystallin. Developmental Neurobiology. 75(5):505-21
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