tnnc1b

ID

ZDB-GENE-040625-62

Name

troponin C type 1b (slow)

Symbol

tnnc1b Nomenclature History

Previous Names

stnnc
ssTnC (1)
zgc:86932

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and troponin I binding activity. Acts upstream of or within cardiac muscle contraction. Predicted to be part of cardiac Troponin complex. Is expressed in adaxial cell; heart; musculature system; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6899234 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnnc1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1Z	Alliance	Cardiomyopathy, dilated, 1Z	611879
hypertrophic cardiomyopathy 13	Alliance	Cardiomyopathy, hypertrophic, 13	613243

Associated With tnnc1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Family	IPR050230	Calmodulin/Myosin light chain/Troponin C-like
Homologous_superfamily	IPR011992	EF-hand domain pair