Gene
actc2
- ID
- ZDB-GENE-040625-35
- Name
- actin, alpha, cardiac muscle 2
- Symbol
- actc2 Nomenclature History
- Previous Names
-
- zgc:86709 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Predicted to be active in actin cytoskeleton. Is expressed in heart tube and post-vent region. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1).
- Genome Resources
- Note
-
The nomenclature for this gene was based on evidence from Witjes et al. (2019) and in collaboration with HGNC and MGI.
- Comparative Information
-
- All Expression Data
- 2 figures from Ojehomon et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin/actin-like conserved site | Actin, conserved site | Actin family | ATPase, nucleotide binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6IQL9 | InterPro | 377 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260D9 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1C22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86709 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174767 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002066 (1) | 1436 nt | ||
| Genomic | GenBank:AL645822 (2) | 181112 nt | ||
| Polypeptide | UniProtKB:Q6IQL9 (1) | 377 aa |
No data available
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Ojehomon, M., Alderman, S.L., Sandhu, L., Sutcliffe, S., Van Raay, T., Gillis, T.E., Dawson, J.F. (2018) Identification of the actc1c cardiac actin gene in zebrafish. Progress in Biophysics and Molecular Biology. 138:32-37
- Gunning, P.W., Ghoshdastider, U., Whitaker, S., Popp, D., Robinson, R.C. (2015) The evolution of compositionally and functionally distinct actin filaments. Journal of Cell Science. 128:2009-19
- Magdeldin, S., Blaser, R., Yamamoto, T., Yates, J.R. (2015) Behavioral and Proteomic Analysis of Stress Response in Zebrafish (Danio rerio). Journal of Proteome Research. 14(2):943-52
- Yin, X., Wang, H., Zhang, Y., Dahlgren, R.A., Zhang, H., Shi, M., Gao, M., Wang, X. (2014) Toxicological Assessment of Trace β-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis. PLoS One. 9:e102731
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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