Gene

actc2

ID
ZDB-GENE-040625-35
Name
actin, alpha, cardiac muscle 2
Symbol
actc2 Nomenclature History
Previous Names
  • zgc:86709 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Predicted to be part of dynactin complex. Is expressed in heart tube and post-vent region. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1).
Genome Resources
Note
The nomenclature for this gene was based on evidence from Witjes et al. (2019) and in collaboration with HGNC and MGI.
Comparative Information
Expression
All Expression Data
2 figures from Ojehomon et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With actc2 Human Ortholog
No data available
Associated With actc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR004001 Actin, conserved site
Conserved_site IPR020902 Actin/actin-like conserved site
Family IPR004000 Actin family
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length Actin/actin-like conserved site Actin, conserved site Actin family ATPase, nucleotide binding domain
UniProtKB:A0A2R8RJJ2 148
UniProtKB:Q6IQL9 377
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations