Gene
mafga
- ID
- ZDB-GENE-040624-7
- Name
- v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ga
- Symbol
- mafga Nomenclature History
- Previous Names
-
- mafg1
- sb:eu622
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Contributes to DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-templated transcription. Part of transcription regulator complex. Is expressed in brain and ventricular zone. Orthologous to human MAFG (MAF bZIP transcription factor G).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu622 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16857 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004826 | Basic leucine zipper domain, Maf-type |
| Domain | IPR004827 | Basic-leucine zipper domain |
| Family | IPR024874 | Transcription factor Maf family |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Basic-leucine zipper domain superfamily | Transcription factor Maf family | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6I6N2 | InterPro | 162 | |||||
| UniProtKB:A0A8M2BBH6 | InterPro | 212 | |||||
| UniProtKB:A0A8M9P5V5 | InterPro | 234 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-300I13 | ZFIN Curated Data | |
| Encodes | EST | eu622 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:195061 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195098 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002045 (1) | 592 nt | ||
| Genomic | GenBank:CU633742 (2) | 38677 nt | ||
| Polypeptide | UniProtKB:A0A8M9P5V5 (1) | 234 aa |
- Chen, C., He, M., Li, X., Yu, L., Liu, Y., Yang, Y., Li, L., Jia, J., Li, B. (2022) H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish. Life (Basel, Switzerland). 12(9)
- Weil, M., Scholz, S., Zimmer, M., Sacher, F., and Duis, K. (2009) Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environmental toxicology and chemistry. 28(9):1970-1978
- Takagi, Y., Kobayashi, M., Li, L., Suzuki, T., Nishikawa, K, and Yamamoto, M. (2004) MafT, a new member of the small Maf protein family in zebrafish. Biochemical and Biophysical Research Communications. 320(1):62-69
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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