Gene
isl1b
- ID
- ZDB-GENE-040624-1
- Name
- ISL LIM homeobox 1b
- Symbol
- isl1b Nomenclature History
- Previous Names
-
- isl1l
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047244 | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 |
| Family | IPR047169 | Insulin gene enhancer protein ISL-1/2-like |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TEN0 | InterPro | 323 |
Interactions and Pathways
No data available
Plasmids
No data available