Gene
nrp1b
- ID
- ZDB-GENE-040611-1
- Name
- neuropilin 1b
- Symbol
- nrp1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable semaphorin receptor activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and positive regulation of filopodium assembly. Acts upstream of or within several processes, including regulation of vascular endothelial growth factor receptor signaling pathway; response to hypoxia; and vasculature development. Predicted to be located in membrane. Predicted to be active in axon; focal adhesion; and plasma membrane. Is expressed in cranial neural crest cell; mid cerebral vein; retinal ganglion cell layer; somite; and trunk vasculature. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR022579 | Neuropilin, C-terminal |
| Family | IPR014648 | Neuropilin |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | Galactose-binding-like domain superfamily | MAM domain | Neuropilin | Neuropilin, C-terminal | Neuropilin/Multicopper Oxidase/Coagulation Factor | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6T870
|
959 |
Interactions and Pathways
No data available
Plasmids
No data available