Gene
asic1b
- ID
- ZDB-GENE-040513-1
- Name
- acid-sensing (proton-gated) ion channel 1b
- Symbol
- asic1b Nomenclature History
- Previous Names
-
- zASIC1.1 (1)
- accn2a
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables ligand-gated sodium channel activity. Predicted to be involved in cellular response to pH; protein homotrimerization; and sodium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and sodium ion transport. Located in plasma membrane. Is expressed in gill and integument. Orthologous to human ASIC1 (acid sensing ion channel subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43763 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Epithelial sodium channel | Epithelial sodium channel, chordates | Epithelial sodium channel, conserved site |
|---|---|---|---|---|---|
| UniProtKB:B3DGD8 | InterPro | 557 | |||
| UniProtKB:A0A8M2B8J9 | InterPro | 523 | |||
| UniProtKB:A0A0R4ID46 | InterPro | 537 | |||
| UniProtKB:Q708S8 | InterPro | 557 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
asic1b-201
(1)
|
Ensembl | 2,662 nt | ||
| mRNA |
asic1b-202
(1)
|
Ensembl | 3,282 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-106J5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-157P5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194012 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194024 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214791 (1) | 2684 nt | ||
| Genomic | GenBank:BX511034 (1) | 284624 nt | ||
| Polypeptide | UniProtKB:B3DGD8 (1) | 557 aa |
- Cocco, A. (2018) The γ-aminobutyric acid and proton signaling systems in the zebrafish brain Characterization and effect of stress. Ph.D. Thesis.
- Wang, X., Zheng, Y., Zhang, Y., Li, J., Zhang, H., Wang, H. (2016) Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Chemosphere. 144:2195-2205
- Dymowska, A.K., Boyle, D., Schultz, A.G., Goss, G.G. (2015) The role of acid-sensing ion channels (ASICs) in epithelial Na+ uptake in adult zebrafish (Danio rerio). The Journal of experimental biology. 218(Pt 8):1244-51
- Dymowska, A.K., Schultz, A.G., Blair, S.D., Chamot, D., Goss, G.G. (2014) Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss. American journal of physiology. Cell physiology. 307(3):C255-65
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- Viña, E., Parisi, V., Cabo, R., Laurà, R., López-Velasco, S., López-Muñiz, A., García-Suárez, O., Germanà, A., and Vega, J.A. (2013) Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish. Neuroscience letters. 536:35-40
- Paukert, M., Sidi, S., Russell, C., Siba, M., Wilson, S.W., Nicolson, T., and Grunder, S. (2004) A family of acid-sensing ion channels (ASICs) from the zebrafish: Widespread expression in the central nervous system suggests a conserved role in neuronal communication. The Journal of biological chemistry. 279(18):18783-18791
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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