gdf11

ID

ZDB-GENE-040427-2

Name

growth differentiation factor 11

Symbol

gdf11 Nomenclature History

Previous Names

bmp11 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within anterior/posterior pattern specification; cranial skeletal system development; and regulation of cartilage development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; gonad; head; intermediate cell mass of mesoderm; and tail bud. Human ortholog(s) of this gene implicated in vertebral hypersegmentation and orofacial anomalies. Orthologous to human GDF11 (growth differentiation factor 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gdf11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vertebral hypersegmentation and orofacial anomalies	Alliance	?Vertebral hypersegmentation and orofacial anomalies	619122

Associated With gdf11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine