ZFIN ID: ZDB-GENE-040426-933
Gene Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Gene Symbol: tab2    Nomenclature History

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Previous Names: Tab2 (1), map3k7ip2, zgc:77446

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; convergent extension involved in gastrulation; and heart development. Is expressed in bulbus arteriosus; dorsal aorta; and posterior cardinal vein. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2).
Genome Resources: Alliance (1),  Gene:494163 (1),  Ensembl(GRCz11):ENSDARG00000021509 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013779Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021394Tg Transgenic Insertion Unknown Unknown DNA
    sa6611 Point Mutation Unknown Premature Stop ENU
    sa36936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa36937 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tab2 N/A 1
    MO2-tab2 N/A 1
    DISEASE ASSOCIATED WITH tab2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Congenital heart defects, nonsyndromic, 2 614980
    DISEASE ASSOCIATED WITH tab2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001876 Zinc finger, RanBP2-type
    Domain IPR003892 Ubiquitin system component CUE
    Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
    Domain IPR041911 TAB2/3, CUE domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tab2-201 (1)    Ensembl 3969
    tab2-202 (1)    Ensembl 486
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tab2 No data available
    MARKER RELATIONSHIPS
    tab2 Contained in: [BAC] CH211-200P13 (1)
    tab2 Encodes: [cDNA] MGC:77446 (1)
    tab2 Has Artifact: [cDNA] MGC:56186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009900 (1) 2152 bp
    Genomic GenBank:CR536610 (1) 89050 bp
    Select Tool
    Polypeptide UniProtKB:Q5RFW2 (1) 711 aa
    Sequence Information (all 15)
    ORTHOLOGY for tab2 ( Chr: 20 )
    CITATIONS (25)