Gene
tab2
- ID
- ZDB-GENE-040426-933
- Name
- TGF-beta activated kinase 1 (MAP3K7) binding protein 2
- Symbol
- tab2 Nomenclature History
- Previous Names
-
- Tab2 (1)
- map3k7ip2
- zgc:77446
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Involved in heart development. Acts upstream of or within chordate embryonic development and convergent extension involved in gastrulation. Predicted to be located in cytosol and membrane. Is expressed in bulbus arteriosus; dorsal aorta; and posterior cardinal vein. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thienpont et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thienpont et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Congenital heart defects, nonsyndromic, 2 | 614980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TAB2/3, CUE domain | Ubiquitin system component CUE | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z392
|
750 | ||||
|
UniProtKB:Q5RFW2
|
711 |
Interactions and Pathways
No data available
Plasmids
No data available