Gene
trim36
- ID
- ZDB-GENE-040426-2936
- Name
- tripartite motif containing 36
- Symbol
- trim36 Nomenclature History
- Previous Names
-
- wu:fj48f01
- zgc:153447
- zgc:63476
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in acrosome reaction and spindle organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in acrosomal vesicle. Is expressed in nervous system. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human TRIM36 (tripartite motif containing 36).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63476 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016407Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029494Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anencephaly | Alliance | ?Anencephaly 1 | 206500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR000315 | B-box-type zinc finger |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001870 | B30.2/SPRY domain |
| Domain | IPR003877 | SPRY domain |
| Domain | IPR003879 | Butyrophylin-like, SPRY domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR017903 | COS domain |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Domain | IPR027726 | E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass |
| Domain | IPR040859 | Midline-1, COS domain |
| Domain | IPR047065 | E3 ubiquitin-protein ligase Trim36, B-box-type 2 zinc finger |
| Domain | IPR047066 | E3 ubiquitin-protein ligase Trim36, B-box-type 1 zinc finger |
| Family | IPR050617 | E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR043136 | B30.2/SPRY domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | B-box-type zinc finger | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | COS domain | E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins | E3 ubiquitin-protein ligase Trim36, B-box-type 1 zinc finger | E3 ubiquitin-protein ligase Trim36, B-box-type 2 zinc finger | E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Midline-1, COS domain | SPRY domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A1L1F2 | InterPro | 721 | |||||||||||||||||||
| UniProtKB:A0A8N1TT84 | InterPro | 747 | |||||||||||||||||||
| UniProtKB:A0AB13A9A8 | InterPro | 759 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trim36-201
(1)
|
Ensembl | 3,446 nt | ||
| mRNA |
trim36-202
(1)
|
Ensembl | 2,214 nt | ||
| mRNA |
trim36-204
(1)
|
Ensembl | 776 nt | ||
| mRNA |
trim36-205
(1)
|
Ensembl | 878 nt | ||
| mRNA |
trim36-206
(1)
|
Ensembl | 1,326 nt | ||
| ncRNA |
trim36-004
(1)
|
Ensembl | 590 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001362441 (1) | 3612 nt | ||
| Genomic | GenBank:FP017151 (2) | 27204 nt | ||
| Polypeptide | UniProtKB:A0AB13A9A8 (1) | 759 aa |
- Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M., Junker, J.P. (2021) Spatio-temporal mRNA tracking in the early zebrafish embryo. Nature communications. 12:3358
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sullivan, C., Lage, C.R., Yoder, J.A., Postlethwait, J.H., Kim, C.H. (2017) Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts. PLoS One. 12:e0179517
- Tokarz, D.A., Heffelfinger, A.K., Jima, D.D., Gerlach, J., Shah, R.N., Rodriguez-Nunez, I., Kortum, A.N., Fletcher, A.A., Nordone, S.K., Law, J.M., Heber, S., Yoder, J.A. (2017) Disruption of Trim9 function abrogates macrophage motility in vivo. Journal of Leukocyte Biology. 102(6):1371-1380
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish. PLoS One. 6(7):e22022
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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