Gene
gsta.1
- ID
- ZDB-GENE-040426-2720
- Name
- glutathione S-transferase, alpha tandem duplicate 1
- Symbol
- gsta.1 Nomenclature History
- Previous Names
-
- Gsta2 (1)
- gstal
- wu:fk08d06
- zgc:73173
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Is expressed in several structures, including epidermis; intestinal bulb primordium; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1) and GSTA2 (glutathione S-transferase alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162905 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012460Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018748Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018749Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027481Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Family | IPR003080 | Glutathione S-transferase, alpha class |
| Family | IPR040079 | Glutathione transferase family |
| Family | IPR050213 | Glutathione S-transferase superfamily |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, alpha class | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione S-transferase superfamily | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P962 | InterPro | 223 | ||||||||
| UniProtKB:F1R4Z8 | InterPro | 223 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gsta.1-201
(1)
|
Ensembl | 944 nt | ||
| ncRNA |
gsta.1-002
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158E23 | ZFIN Curated Data | |
| Encodes | EST | fk08d06 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7162905 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:73173 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213394 (1) | 1109 nt | ||
| Genomic | GenBank:AL929536 (1) | 151341 nt | ||
| Polypeptide | UniProtKB:F1R4Z8 (1) | 223 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- There are atleast 5 human GSTA genes making it difficult to establish orthology. Removing orthology data attribution from ZDB-PUB-080506-10 and ZDB-PUB-050823-6.
No data available
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Navarrete, J., Wilson, P., Allsing, N., Gordon, C., Margolis, R., Schwartz, A.V., Cho, C., Rogowski, B., Topps, J., George, U.Z., Sant, K.E. (2021) The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 235:105815
- Biswas, S., Ghosh, S., Samanta, A., Das, S., Mukherjee, U., Maitra, S. (2020) Bisphenol A impairs reproductive fitness in zebrafish ovary: Potential involvement of oxidative/nitrosative stress, inflammatory and apoptotic mediators. Environmental pollution (Barking, Essex : 1987). 267:115692
- Tierbach, A., Groh, K.J., Schoenenberger, R., Schirmer, K., Suter, M.J. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: Functionality of the mercapturic acid pathway. Toxicological sciences : an official journal of the Society of Toxicology. 176(2):355-365
- Viganò, L., Casatta, N., Farkas, A., Mascolo, G., Roscioli, C., Stefani, F., Vitelli, M., Olivo, F., Clerici, L., Robles, P., Dellavedova, P. (2020) Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments. Environmental science and pollution research international. 27(10):10729-10747
- Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
- Chemello, G., Randazzo, B., Zarantoniello, M., Fifi, A.P., Aversa, S., Ballarin, C., Radaelli, G., Magro, M., Olivotto, I. (2019) Safety assessment of antibiotic administration by magnetic nanoparticles in in vitro zebrafish liver and intestine cultures. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 224:108559
- Brown, S.E., Sant, K.E., Fleischman, S.M., Venezia, O., Roy, M.A., Zhao, L., Timme-Laragy, A.R. (2018) Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio). Birth defects research. 110(11):933-948
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