Gene
rnf170
- ID
- ZDB-GENE-040426-2572
- Name
- ring finger protein 170
- Symbol
- rnf170 Nomenclature History
- Previous Names
-
- zgc:65779
- zgc:76995 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and ubiquitin protein ligase activity. Involved in chordate embryonic development. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1. Orthologous to human RNF170 (ring finger protein 170).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76995 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant sensory ataxia 1 | Alliance | Ataxia, sensory, 1, autosomal dominant | 608984 |
| hereditary spastic paraplegia 85 | Alliance | Spastic paraplegia 85, autosomal recessive | 619686 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hereditary spastic paraplegia | WT + MO3-rnf170 | standard conditions | Wagner et al., 2019 |
| hereditary spastic paraplegia | WT + MO4-rnf170 | standard conditions | Wagner et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR010652 | Domain of unknown function DUF1232 |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Family | IPR038896 | E3 ubiquitin-protein ligase RNF170 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | Domain of unknown function DUF1232 | E3 ubiquitin-protein ligase RNF170 | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SZN2
|
266 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available