Gene

eef1akmt1

ID

ZDB-GENE-040426-2551

Name

EEF1A lysine methyltransferase 1

Symbol

eef1akmt1 Nomenclature History

Previous Names

n6amt2
zgc:77010 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77010 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With eef1akmt1 Human Ortholog

No data available

Associated With eef1akmt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002052	DNA methylase, N-6 adenine-specific, conserved site
Family	IPR019369	Protein-lysine N-methyltransferase Efm5/EEF1AKMT1
Family	IPR041370	Methyltransferase EEF1AKMT1/ZCCHC4
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	DNA methylase, N-6 adenine-specific, conserved site	Methyltransferase EEF1AKMT1/ZCCHC4	Protein-lysine N-methyltransferase Efm5/EEF1AKMT1	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:A0A8M2BEZ0	InterPro	216
UniProtKB:Q6NYP8	InterPro	166

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 9

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	eef1akmt1-201 (1) Ensembl	Ensembl		1,268 nt	Select Tool ZFIN BLAST
mRNA	eef1akmt1-202 (1) Ensembl	Ensembl		948 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-51D17	CR392366	ZFIN Curated Data
Encodes	cDNA	MGC:77010	BC066508	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_207087 (1)	1293 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR392366 (1)	125898 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M2BEZ0 (1)	216 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	EEF1AKMT1	13	Ensembl:ENSG00000150456 Gene:221143 HGNC:27351 OMIM:617793	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Eef1akmt1	14	Ensembl:ENSMUSG00000021951 Gene:68043 MGI:1915293	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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