Gene
map3k12
- ID
- ZDB-GENE-040426-2436
- Name
- mitogen-activated protein kinase kinase kinase 12
- Symbol
- map3k12 Nomenclature History
- Previous Names
-
- zgc:77370
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in JNK cascade. Predicted to act upstream of or within protein autophosphorylation. Predicted to be active in cytoplasm. Is expressed in central nervous system; cranial ganglion; neural tube; neurons; and retina. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77370 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Adula et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Family | IPR017419 | Mitogen-activated protein kinase kinase kinase 12/13 |
| Family | IPR027257 | Mitogen-activated protein kinase kinase kinase 12 |
| Family | IPR050167 | Serine/threonine-protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase kinase kinase 12 | Mitogen-activated protein kinase kinase kinase 12/13 | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NYW1
|
856 | |||||||
|
UniProtKB:A0A8M2BER7
|
897 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | map3k12-001 (1) | 3,666 nt | |||
| mRNA |
map3k12-201
(1)
|
Ensembl | 3,532 nt |
Interactions and Pathways
No data available
Plasmids
No data available