Gene

prkar2ab

ID

ZDB-GENE-040426-2427

Name

protein kinase, cAMP-dependent, regulatory, type II, alpha, B

Symbol

prkar2ab Nomenclature History

Previous Names

prkar2a
zgc:85886

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85886 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkar2ab Human Ortholog

No data available

Associated With prkar2ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018488	Cyclic nucleotide-binding, conserved site
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR003117	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Family	IPR012198	cAMP-dependent protein kinase regulatory subunit
Family	IPR050503	cAMP-dependent kinase regulatory chain
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily