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Gene

ednrab

ID
ZDB-GENE-040426-2364
Name
endothelin receptor type Ab
Symbol
ednrab Nomenclature History
Previous Names
  • ednrA1 (1)
  • zgc:85942 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable endothelin receptor activity. Acts upstream of or within cardioblast migration to the midline involved in heart rudiment formation; cartilage development; and embryonic viscerocranium morphogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in cranial ganglion; gill; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ednrab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mandibulofacial dysostosis with alopecia Alliance Mandibulofacial dysostosis with alopecia 616367
migraine Alliance {Migraine, resistance to} 157300
Associated With ednrab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000499 Endothelin receptor family
Family IPR002175 Endothelin receptor A
Domain Details Per Protein
Protein Length Endothelin receptor A Endothelin receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:A0A0B5JSA7 68
UniProtKB:A8WGR7 328
UniProtKB:F8W4W1 408
UniProtKB:Q6NW64 363
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations