Gene
dnase1l1
- ID
- ZDB-GENE-040426-2170
- Name
- deoxyribonuclease I-like 1
- Symbol
- dnase1l1 Nomenclature History
- Previous Names
-
- dnase1l3
- wu:fb44e02
- zgc:66031
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; hatching gland; polster; and pronephric duct. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66031 (1 image)
- IMAGE:7148095 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Deoxyribonuclease I | Deoxyribonuclease I, active site | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:F1QBE2 | InterPro | 317 | ||||
| UniProtKB:Q7SZQ1 | InterPro | 315 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnase1l1-201
(1)
|
Ensembl | 1,741 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-93L1 | ZFIN Curated Data | |
| Encodes | EST | fb44e02 | ||
| Encodes | EST | IMAGE:7148095 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66031 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213153 (1) | 1691 nt | ||
| Genomic | GenBank:CR450723 (1) | 234987 nt | ||
| Polypeptide | UniProtKB:F1QBE2 (1) | 317 aa |
- Zhang, J., Cui, W.W., Du, C., Huang, Y., Pi, X., Guo, W., Wang, J., Huang, W., Chen, D., Li, J., Li, H., Zhang, J., Ma, Y., Mu, H., Zhang, S., Liu, M., Cui, X., Hu, Y. (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1866:165724
- Fodor, E., Zsigmond, A., Horváth, B., Molnár, J., Nagy, I., Tóth, G., Wilson, S.W., and Varga, M. (2013) Full transcriptome analysis of early dorsoventral patterning in zebrafish. PLoS One. 8(7):e70053
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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