Gene
foxd1
- ID
- ZDB-GENE-040426-2094
- Name
- forkhead box D1
- Symbol
- foxd1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in immature eye; nervous system; neural crest; pharyngeal arch; and presumptive diencephalon. Orthologous to human FOXD1 (forkhead box D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76875 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hernández-Bejarano et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Forkhead box domain-containing protein | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A2CE80
|
343 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195C22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76875 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212913 (1) | 1791 nt | ||
| Genomic | GenBank:BX530075 (1) | 176078 nt | ||
| Polypeptide | UniProtKB:A2CE80 (1) | 343 aa |
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Hernández-Bejarano, M., Gestri, G., Monfries, C., Tucker, L., Dragomir, E.I., Bianco, I.H., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2022) Foxd1-dependent induction of a temporal retinal character is required for visual function. Development (Cambridge, England). 149(24):
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
- Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2021) Retinal Pigment Epithelium and Neural Retinal Progenitors Interact Via Semaphorin 6D to Facilitate Optic Cup Morphogenesis. eNeuro. 8(3):
- DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
- Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K. (2019) Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling. Developmental Biology. 452(1):43-54
- Hocking, J.C., Famulski, J.K., Yoon, K.H., Widen, S.A., Bernstein, C.S., Koch, S., Weiss, O., FORGE Canada Consortium, Agarwala, S., Inbal, A., Lehmann, O.J., Waskiewicz, A.J. (2018) Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye. PLoS Genetics. 14:e1007246
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