Gene
zgc:77938
- ID
- ZDB-GENE-040426-1910
- Name
- zgc:77938
- Symbol
- zgc:77938 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to localize to cytosol. Is expressed in intestinal bulb and liver. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77938 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
| Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
| Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
| Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | Alcohol dehydrogenase, zinc-type, conserved site | GroES-like superfamily | NAD(P)-binding domain superfamily | Polyketide synthase, enoylreductase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZZ1
|
378 | ||||||
|
UniProtKB:A0A8M2B456
|
431 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
zgc:77938-201
(1)
|
Havana | 1357 nt | |
| ncRNA |
zgc:77938-002
(1)
|
Havana | 776 nt |
Interactions and Pathways
No data available
Plasmids
No data available