Gene

zgc:77938

ID
ZDB-GENE-040426-1910
Name
zgc:77938
Symbol
zgc:77938 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to localize to cytosol. Is expressed in intestinal bulb and liver. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zgc:77938 Human Ortholog
No data available
Associated With zgc:77938 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013154 Alcohol dehydrogenase-like, N-terminal
Domain IPR020843 Polyketide synthase, enoylreductase domain
Homologous_superfamily IPR011032 GroES-like superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Alcohol dehydrogenase-like, C-terminal Alcohol dehydrogenase-like, N-terminal Alcohol dehydrogenase, zinc-type, conserved site GroES-like superfamily NAD(P)-binding domain superfamily Polyketide synthase, enoylreductase domain
UniProtKB:Q6NZZ1 378
UniProtKB:A0A8M2B456 431
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations