Gene
gcdha
- ID
- ZDB-GENE-040426-1855
- Name
- glutaryl-CoA dehydrogenase a
- Symbol
- gcdha Nomenclature History
- Previous Names
-
- gcdh
- zgc:77704 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and fatty-acyl-CoA biosynthetic process. Predicted to be located in mitochondrial matrix. Is expressed in alar plate midbrain region; eye; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glutaric acidemia I | Alliance | Glutaricaciduria, type I | 231670 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006089 | Acyl-CoA dehydrogenase, conserved site |
| Domain | IPR006091 | Acyl-CoA oxidase/dehydrogenase, middle domain |
| Domain | IPR009075 | Acyl-CoA dehydrogenase/oxidase, C-terminal |
| Domain | IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| Family | IPR052033 | Mitochondrial Glutaryl-CoA Dehydrogenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA dehydrogenase, conserved site | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase, C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase/dehydrogenase, middle domain | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily | Mitochondrial Glutaryl-CoA Dehydrogenase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P3I8 | InterPro | 441 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276A17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77704 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:56505 | ZFIN Curated Data |
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Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200886 (1) | 1904 nt | ||
| Genomic | GenBank:AL772339 (1) | 166809 nt | ||
| Polypeptide | UniProtKB:Q6P3I8 (1) | 441 aa |