Gene
dusp8a
- ID
- ZDB-GENE-040426-1842
- Name
- dual specificity phosphatase 8a
- Symbol
- dusp8a Nomenclature History
- Previous Names
-
- zgc:77593
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Is expressed in nervous system and neural rod. Orthologous to human DUSP8 (dual specificity phosphatase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77593 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Domain | IPR048035 | Dual specificity protein phosphatase 8, dual specificity phosphatase domain |
| Family | IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase 8, dual specificity phosphatase domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P3L8
|
629 | |||||||||
|
UniProtKB:F1QVZ9
|
629 | |||||||||
|
UniProtKB:A0A8M2BI12
|
545 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dusp8a-201
(1)
|
Ensembl | 3,407 nt |
Interactions and Pathways
No data available
Plasmids
No data available