Gene

dusp8a

ID
ZDB-GENE-040426-1842
Name
dual specificity phosphatase 8a
Symbol
dusp8a Nomenclature History
Previous Names
  • zgc:77593
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Is expressed in nervous system and neural rod. Orthologous to human DUSP8 (dual specificity phosphatase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa866Allele with one point mutationUnknownPremature StopENU
sa38077Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With dusp8a Human Ortholog
No data available
Associated With dusp8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000340 Dual specificity phosphatase, catalytic domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR001763 Rhodanese-like domain
Domain IPR020422 Dual specificity protein phosphatase domain
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Domain Details Per Protein
Protein Additional Resources Length Dual specificity phosphatase, catalytic domain Dual specificity protein phosphatase 8, dual specificity phosphatase domain Dual specificity protein phosphatase domain Mitogen-activated protein (MAP) kinase phosphatase Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase-like Rhodanese-like domain Rhodanese-like domain superfamily Tyrosine-specific protein phosphatases domain
UniProtKB:Q6P3L8 InterPro 629
UniProtKB:F1QVZ9 InterPro 629
UniProtKB:A0A8M2BI12 InterPro 545
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dusp8a-201 (1) Ensembl 3,407 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-100J24ZFIN Curated Data
Contained inBACCH73-242B11ZFIN Curated Data
Contained inBACDKEY-238H7ZFIN Curated Data
EncodescDNAMGC:77593ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDUSP811
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseDusp87
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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