Gene

cnksr1

ID

ZDB-GENE-040426-1802

Name

connector enhancer of kinase suppressor of Ras 1

Symbol

cnksr1 Nomenclature History

Previous Names

zgc:77200

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa6479	Allele with one point mutation	Unknown	Splice Site	ENU
sa42946	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa45610	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With cnksr1 Human Ortholog

No data available

Associated With cnksr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR017874	CRIC domain
Domain	IPR049628	CNK1-3, SAM domain

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Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3ARE5	InterPro	628
UniProtKB:Q6P0K1	InterPro	780
UniProtKB:A0A8M3AJV6	InterPro	790
UniProtKB:A0A8M3AUB2	InterPro	770
UniProtKB:A0AB32T8R3	InterPro	798

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cnksr1-201 (1) Ensembl	Ensembl		2,537 nt	Select Tool ZFIN BLAST
mRNA	cnksr1-202 (1) Ensembl	Ensembl		2,491 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-212B24	CR385084	ZFIN Curated Data
Contained in	BAC	DKEY-221L4	AL928908	ZFIN Curated Data
Contained in	BAC	DKEYP-7D4	BX324199	ZFIN Curated Data
Encodes	cDNA	MGC:77200	BC065587	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_205659 (1)	3816 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL928908 (1)	229790 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0AB32T8R3 (1)	798 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	CNKSR1	1	Ensembl:ENSG00000142675 Gene:10256 HGNC:19700 OMIM:603272	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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