Gene

ppcdc

ID

ZDB-GENE-040426-1749

Name

phosphopantothenoylcysteine decarboxylase

Symbol

ppcdc Nomenclature History

Previous Names

zgc:73297 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable FMN binding activity and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73297 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With ppcdc Human Ortholog

No data available

Associated With ppcdc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003382	Flavoprotein
Homologous_superfamily	IPR036551	Flavin prenyltransferase-like

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Domain Details Per Protein

Protein	Additional Resources	Length	Flavin prenyltransferase-like	Flavoprotein
UniProtKB:A0A8M3AJI9	InterPro	231
UniProtKB:Q6PBQ5	InterPro	203

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 18

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ppcdc-201 (1) Ensembl	Ensembl		1,886 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-117I10	BX548060	ZFIN Curated Data
Encodes	cDNA	MGC:73297	BC059622	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200780 (1)	1914 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571883 (1)	253172 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M3AJI9 (1)	231 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PPCDC	15	Ensembl:ENSG00000138621 Gene:60490 HGNC:28107 OMIM:609854	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Ppcdc	9	Ensembl:ENSMUSG00000063849 Gene:66812 MGI:1914062	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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