Gene
shmt1
- ID
- ZDB-GENE-040426-1558
- Name
- serine hydroxymethyltransferase 1 (soluble)
- Symbol
- shmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Exhibits glycine hydroxymethyltransferase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to tetrahydrofolate; and protein homotetramerization. Localizes to cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is expressed in several structures, including digestive system; immature eye; midbrain; neural tube; and oocyte. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910517 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019798 | Serine hydroxymethyltransferase, pyridoxal phosphate binding site |
| Domain | IPR039429 | Serine hydroxymethyltransferase-like domain |
| Family | IPR001085 | Serine hydroxymethyltransferase |
| Family | IPR049943 | Serine hydroxymethyltransferase-like |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Serine hydroxymethyltransferase | Serine hydroxymethyltransferase-like | Serine hydroxymethyltransferase-like domain | Serine hydroxymethyltransferase, pyridoxal phosphate binding site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SXN1
|
481 |
Interactions and Pathways
No data available
Plasmids
No data available