Gene

slc22a4

ID

ZDB-GENE-040426-1517

Name

solute carrier family 22 member 4

Symbol

slc22a4 Nomenclature History

Previous Names

octn1 (1)
zgc:66036

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have quaternary ammonium group transmembrane transporter activity. Involved in several processes, including detoxification of mercury ion; response to methylmercury; and selenium compound metabolic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is expressed in eye; head; heart; and skeletal muscle. Orthologous to human SLC22A4 (solute carrier family 22 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc22a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
rheumatoid arthritis	Alliance	{Rheumatoid arthritis, susceptibility to}	180300

Associated With slc22a4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005829	Sugar transporter, conserved site
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR005828	Major facilitator, sugar transporter-like
Family	IPR045915	Solute carrier family 22 members 4/5
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Length	Major facilitator, sugar transporter-like	Major facilitator superfamily domain	MFS transporter superfamily	Solute carrier family 22 members 4/5	Sugar transporter, conserved site
UniProtKB:Q6P695 InterPro	553
UniProtKB:A0A8M9PCI7 InterPro	529
UniProtKB:A0A8M2BHP0 InterPro	327

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc22a4-201 (1) Ensembl	Ensembl	1,766 nt	Select Tool ZFIN BLAST
ncRNA	slc22a4-002 (1) Ensembl	Ensembl	897 nt	Select Tool ZFIN BLAST
ncRNA	slc22a4-003 (1) Ensembl	Ensembl	824 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations