Gene

fzd6

ID

ZDB-GENE-040426-1451

Name

frizzled class receptor 6

Symbol

fzd6 Nomenclature History

Previous Names

zgc:65879
zgc:77440

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within angiogenesis and embryonic cranial skeleton morphogenesis. Predicted to be located in apical plasma membrane; cell surface; and cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Is expressed in head; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77440 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fzd6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nonsyndromic congenital nail disorder 1	Alliance	Nail disorder, nonsyndromic congenital, 1	161050

Associated With fzd6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000539	Frizzled/Smoothened, 7TM
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR020067	Frizzled domain
Domain	IPR041770	Frizzled 6, cysteine-rich domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily

Domain Details Per Protein

Protein	Length	Frizzled 6, cysteine-rich domain	Frizzled cysteine-rich domain superfamily	Frizzled domain	Frizzled/secreted frizzled-related protein	Frizzled/Smoothened, 7TM	GPCR, family 2-like, 7TM
UniProtKB:Q6P0Y7 InterPro	617

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fzd6-201 (1) Ensembl	Ensembl		2,851 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations