Gene

ggt1a

ID

ZDB-GENE-040426-1388

Name

gamma-glutamyltransferase 1a

Symbol

ggt1a Nomenclature History

Previous Names

ggt1
zgc:64172 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable glutathione hydrolase activity. Predicted to be involved in several processes, including glutathione catabolic process; peptide modification; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in lens and solid lens vesicle. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64172 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ggt1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
gamma-glutamyl transpeptidase deficiency	Alliance	?Glutathioninuria	231950

Associated With ggt1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000101	Gamma-glutamyltranspeptidase
Homologous_superfamily	IPR029055	Nucleophile aminohydrolases, N-terminal
Homologous_superfamily	IPR043137	Gamma-glutamyltranspeptidase, small subunit
Homologous_superfamily	IPR043138	Gamma-glutamyltranspeptidase, large subunit, C-terminal domain