Gene

cybb

ID
ZDB-GENE-040426-1380
Name
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
Symbol
cybb Nomenclature History
Previous Names
  • gp91 (1)
  • nox2 (1)
  • zgc:64144 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to localize to NADPH oxidase complex. Is expressed in blood; nervous system; and neutrophil. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cybb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 34 Alliance Immunodeficiency 34, mycobacteriosis, X-linked 300645
X-linked chronic granulomatous disease Alliance Chronic granulomatous disease, X-linked 306400
Associated With cybb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013112 FAD-binding 8
Domain IPR013121 Ferric reductase, NAD binding domain
Domain IPR013130 Ferric reductase transmembrane component-like domain
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR000778 Cytochrome b245, heavy chain
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length Cytochrome b245, heavy chain FAD-binding 8 FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Ferric reductase, NAD binding domain Ferric reductase transmembrane component-like domain Riboflavin synthase-like beta-barrel
UniProtKB:A0A286Y943 571
UniProtKB:F1QV52 565
UniProtKB:Q7T2A7 565
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations