Gene
slc44a4
- ID
- ZDB-GENE-040426-1371
- Name
- solute carrier family 44 member 4
- Symbol
- slc44a4 Nomenclature History
- Previous Names
-
- zgc:64108 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have choline transmembrane transporter activity. Involved in neuromast hair cell development and otolith formation. Predicted to localize to apical plasma membrane and integral component of membrane. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Is expressed in several structures, including liver; midbrain; olfactory system; otic vesicle; and pronephric duct. Orthologous to human SLC44A4 (solute carrier family 44 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64108 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ma et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 72 | Alliance | ?Deafness, autosomal dominant 72 | 617606 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| sensorineural hearing loss | AB + MO2-slc44a4 | standard conditions | Ma et al., 2017 |
| sensorineural hearing loss | AB + MO1-slc44a4 | standard conditions | Ma et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007603 | Choline transporter-like |
Domain Details Per Protein
| Protein | Length | Choline transporter-like |
|---|---|---|
|
UniProtKB:Q7T2B0
|
723 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available