Gene
fermt3b
- ID
- ZDB-GENE-040426-1366
- Name
- FERM domain containing kindlin 3b
- Symbol
- fermt3b Nomenclature History
- Previous Names
-
- kindlin-3 (1)
- zgc:64101
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have integrin binding activity. Predicted to be involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Predicted to localize to cell-substrate junction. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (fermitin family member 3).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pluskota et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
leukocyte adhesion deficiency 3 | Alliance | Leukocyte adhesion deficiency, type III | 612840 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR019748 | FERM central domain |
Domain | IPR019749 | Band 4.1 domain |
Domain | IPR037837 | Kindlin/fermitin, PH domain |
Domain | IPR040790 | Kindlin-2, N-terminal |
Family | IPR037843 | Kindlin/fermitin |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
Protein | Length | Band 4.1 domain | FERM central domain | FERM superfamily, second domain | Kindlin-2, N-terminal | Kindlin/fermitin | Kindlin/fermitin, PH domain | PH-like domain superfamily | Pleckstrin homology domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QPN5
|
642 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
fermt3b-201
(1)
|
Havana | 2577 nt |
Interactions and Pathways
No data available
Plasmids
No data available