Gene
cul4a
- ID
- ZDB-GENE-040426-1357
- Name
- cullin 4A
- Symbol
- cul4a Nomenclature History
- Previous Names
-
- zgc:64071
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase binding activity. Involved in erythrocyte development. Acts upstream of or within embryonic pectoral fin morphogenesis; heart development; and otic vesicle morphogenesis. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in brain; heart; and pectoral fin. Orthologous to human CUL4A (cullin 4A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64071 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3203 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cul4a | Yang et al., 2019 | |
| CRISPR2-cul4a | Yang et al., 2019 | |
| CRISPR3-cul4a | Yang et al., 2019 | |
| CRISPR4-cul4a | Yang et al., 2019 | |
| MO1-cul4a | N/A | (2) |
| MO2-cul4a | N/A | (2) |
| MO3-cul4a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cullin | Cullin homology domain | Cullin homology domain superfamily | Cullin, N-terminal | Cullin repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2C1 | InterPro | 635 | |||||
| UniProtKB:A0AB40EBV9 | InterPro | 745 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1608A7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64071 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192718 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201027 (1) | 2899 nt | ||
| Genomic | GenBank:FO681286 (1) | 32293 nt | ||
| Polypeptide | UniProtKB:A0AB40EBV9 (1) | 745 aa |
- Gasanov, E.V., Jędrychowska, J., Kuźnicki, J., Korzh, V. (2021) Evolutionary context can clarify gene names: Teleosts as a case study. BioEssays : news and reviews in molecular, cellular and developmental biology. 43(6):e2000258
- Lescat, L., Véron, V., Mourot, B., Péron, S., Chenais, N., Dias, K., Riera, N., Beaumatin, F., Pinel, K., Priault, M., Panserat, S., Salin, B., Guiguen, Y., Bobe, J., Herpin, A., Seiliez, I. (2020) Chaperone-Mediated Autophagy in the light of evolution: insight from fish. Molecular Biology and Evolution. 37(10):2887-2899
- Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A.J., Handa, H. (2019) Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 15:95-108
- Yang, F., Hu, H., Liu, Y., Shao, M., Shao, C., Gong, Y. (2019) Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death & Disease. 10:388
- Zhao, X., Jiang, B., Hu, H., Mao, F., Mi, J., Li, Z., Liu, Q., Shao, C., Gong, Y. (2015) Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Human molecular genetics. 24(3):853-64
- Fero, K., Bergeron, S.A., Horstick, E.J., Codore, H., Li, G.H., Ono, F., Dowling, J.J., and Burgess, H.A. (2014) Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Disease models & mechanisms. 7(2):289-98
- Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., and Handa, H. (2010) Identification of a primary target of thalidomide teratogenicity. Science (New York, N.Y.). 327(5971):1345-1350
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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