Gene

derl3

ID

ZDB-GENE-040426-1324

Name

derlin 3

Symbol

derl3 Nomenclature History

Previous Names

zgc:63991

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have misfolded protein binding activity and ubiquitin-specific protease binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and ubiquitin-dependent ERAD pathway. Predicted to localize to Hrd1p ubiquitin ligase ERAD-L complex and integral component of endoplasmic reticulum membrane. Orthologous to human DERL3 (derlin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With derl3 Human Ortholog

No data available

Associated With derl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007599	Derlin
Homologous_superfamily	IPR035952	Rhomboid-like superfamily

Domain Details Per Protein

Protein	Length	Derlin	Rhomboid-like superfamily
UniProtKB:F1R121 InterPro	247

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	derl3-201 (1) Ensembl	Ensembl		1,741 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations