Gene

ptger2a

ID
ZDB-GENE-040426-1321
Name
prostaglandin E receptor 2a (subtype EP2)
Symbol
ptger2a Nomenclature History
Previous Names
  • ep2 (1)
  • PRS2 (1)
  • ptger2l
  • zgc:63974
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables prostaglandin E receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within embryonic liver development; exocrine pancreas development; and pronephros development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including endoderm; hematopoietic stem cell; intermediate mesoderm; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptger2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma, nasal polyps, and aspirin intolerance Alliance {Asthma, aspirin-induced, susceptibility to} 208550
Associated With ptger2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000370 Prostacyclin (prostanoid IP) receptor
Family IPR001923 Prostanoid EP2 receptor
Family IPR008365 Prostanoid receptor
Domain Details Per Protein
Protein Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Prostacyclin (prostanoid IP) receptor Prostanoid EP2 receptor Prostanoid receptor
UniProtKB:Q2MV23 368
UniProtKB:Q6PFT8 281
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations