Gene
cldn15a
- ID
- ZDB-GENE-040426-1305
- Name
- claudin 15a
- Symbol
- cldn15a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within digestive tract morphogenesis and tube formation. Located in bicellular tight junction. Is expressed in several structures, including endoderm; gut; intermediate cell mass of mesoderm; mesoderm; and pleuroperitoneal region. Orthologous to human CLDN15 (claudin 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63943 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bagnat et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:Q7T2E7 | InterPro | 222 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cldn15a-201
(1)
|
Ensembl | 5,587 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1C17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63943 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174521 | ZFIN Curated Data |
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- Yan, J., Fang, L., Ni, A., Xi, M., Li, J., Zhou, X., Qian, Q., Wang, Z.J., Wang, X., Wang, H. (2024) Long-Term Neurotoxic Effects and Alzheimer's Disease Risk of Early EHDPP Exposure in Zebrafish: Insights from Molecular Mechanisms to Adult Pathology. Environmental science & technology. 58(43):19152-19164
- Ding, Q., Zhang, Z., Li, Y., Liu, H., Hao, Q., Yang, Y., Ringø, E., Olsen, R.E., Clarke, J.L., Ran, C., Zhou, Z. (2021) Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. iScience. 24:102515
- Zhang, F.L., Yang, Y.L., Zhang, Z., Yao, Y.Y., Xia, R., Gao, C.C., Du, D.D., Hu, J., Ran, C., Liu, Z., Zhou, Z.G. (2021) Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Frontiers in nutrition. 8:726108
- Bruch-Bertani, J.P., Uribe-Cruz, C., Pasqualotto, A., Longo, L., Ayres, R., Bortolin Beskow, C., Luis Barth, A., Lima-Morales, D., Meurer, F., Tayguara, G., Guerreiro, S., da Silveira, T.R., Álvares-da-Silva, M.R., Dall'Alba, V. (2019) Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish. Journal of the American College of Nutrition. 39(2):163-170
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Wu, N., Xu, X., Wang, B., Li, X.M., Cheng, Y.Y., Li, M., Xia, X.Q., Zhang, Y.A. (2019) Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. Fish & shellfish immunology. 97:204-215
- Guo, X., Li, J., Ran, C., Wang, A., Xie, M., Xie, Y., Ding, Q., Zhang, Z., Yang, Y., Zhou, Z. (2018) Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Fish & shellfish immunology. 86:1064-1071
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
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