ZFIN is now using GRCz12tu for Genomic Data
Gene
ldlrb
- ID
- ZDB-GENE-040426-1254
- Name
- low density lipoprotein receptor b
- Symbol
- ldlrb Nomenclature History
- Previous Names
-
- zgc:63759
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hormone binding activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including arteriosclerosis; familial hypercholesterolemia; hepatitis C; migraine without aura; and stroke. Orthologous to human LDLR (low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cho et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypercholesterolemia | Alliance | Hypercholesterolemia, familial, 1 | 143890 |
| familial hypercholesterolemia | Alliance | LDL cholesterol level QTL2 | 143890 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M6Z1D1 | InterPro | 906 |
| UniProtKB:A0AC58JST7 | InterPro | 919 |
| UniProtKB:A0AC58JSV7 | InterPro | 652 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers