ZFIN is now using GRCz12tu for Genomic Data
Gene
ldlrb
- ID
- ZDB-GENE-040426-1254
- Name
- low density lipoprotein receptor b
- Symbol
- ldlrb Nomenclature History
- Previous Names
-
- zgc:63759
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hormone binding activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to be part of signaling receptor complex. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including arteriosclerosis; familial hypercholesterolemia; hepatitis C; migraine without aura; and stroke. Orthologous to human LDLR (low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cho et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypercholesterolemia | Alliance | Hypercholesterolemia, familial, 1 | 143890 |
| familial hypercholesterolemia | Alliance | LDL cholesterol level QTL2 | 143890 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M6Z1D1 | InterPro | 906 |
| UniProtKB:A0AC58JST7 | InterPro | 919 |
| UniProtKB:A0AC58JSV7 | InterPro | 652 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers