Gene

xpnpep2

ID

ZDB-GENE-040426-1151

Name

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

Symbol

xpnpep2 Nomenclature History

Previous Names

zgc:63528

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Tang et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xpnpep2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Angioedema induced by ACE inhibitors, susceptibility to}	300909

Associated With xpnpep2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000587	Creatinase, N-terminal
Domain	IPR000994	Peptidase M24
Domain	IPR032416	Peptidase M24, C-terminal domain
Domain	IPR033740	Aminopeptidase P
Family	IPR050422	Xaa-Pro aminopeptidase P
Homologous_superfamily	IPR029149	Creatinase/Aminopeptidase P/Spt16, N-terminal
Homologous_superfamily	IPR036005	Creatinase/aminopeptidase-like