Gene

pik3cd

ID
ZDB-GENE-040426-1128
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Symbol
pik3cd Nomenclature History
Previous Names
  • zgc:63473 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within regulation of collateral sprouting in absence of injury. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; cranial ganglion; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Schmidt et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3cd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 14 Alliance Immunodeficiency 14A, autosomal dominant 615513
Immunodeficiency 14B, autosomal recessive 619281
?Roifman-Chitayat syndrome, digenic 613328
Associated With pik3cd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
Domain IPR002420 Phosphatidylinositol 3-kinase, C2 domain
Domain IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
Domain IPR037703 PI3Kdelta, catalytic domain
Family IPR015433 Phosphatidylinositol kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain Phosphatidylinositol 3-kinase, C2 domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Phosphatidylinositol kinase Phosphoinositide 3-kinase, accessory (PIK) domain Phosphoinositide 3-kinase, accessory (PIK) domain superfamily PI3Kdelta, catalytic domain Protein kinase-like domain superfamily Ubiquitin-like domain superfamily
UniProtKB:F1RB17 1039
UniProtKB:Q7SYE7 1039
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations