Gene

tlr4ba

ID
ZDB-GENE-040219-8
Name
toll-like receptor 4b, duplicate a
Symbol
tlr4ba Nomenclature History
Previous Names
  • TIR4.1 (1)
  • tlr4a (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Is predicted to enable lipopolysaccharide binding activity and lipopolysaccharide immune receptor activity. Involved in defense response to Gram-negative bacterium; inflammatory response; and toll-like receptor signaling pathway. Acts upstream of or within innate immune response and signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Part of protein-containing complex. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr4ba Human Ortholog
No data available
Associated With tlr4ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Family IPR017241 Toll-like receptor
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor
UniProtKB:Q6TQI0 152
UniProtKB:B8A689 787
UniProtKB:F1QSN2 750
UniProtKB:B3U3W0 750
UniProtKB:A0A2R8RP71 750
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Orthology with AA evidence from Jault C et al (Mol Immunol 40(11), 759-771; ZDB-PUB-040109-34) was deleted in light of data in Sullivan C et al (ZDB-PUB-091023-26). The authors state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.
Citations